Abarelix( Purity > 99% by HPLC)

Product Name: Abarelix
 CAT#: A-2020

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 Synonym:PPI-149; PPI149; PPI 149; R-3827; R3827; R 3827. Abarelix; Abarelix acetate. Brand name: Plenaxis. ,

Abarelix Chemical Structure
Abarelixchemical structure

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IUPAC/Chemical name:

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Biological Activity
Description of Abarelix: Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth
Technical Data

Purity: >99%
CAS#:183552-38-7
Chemical Formula:C72H95ClN14O14
Molecular Weight:1416.06
Abarelix MSDSAbarelix CoA

IUPAC/Chemical name:(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]butanediamide Sequence: Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(ipr)-Pro-D-Ala-NH2
Canonical SMILES:O=C(N[C@@H](CC(C)C)C(N[C@@H](CCCCNC(C)C)C(N1[C@H](C(N[C@H](C)C(N)=O)=O)CCC1)=O)=O)[C@H](NC([C@@H](N(C([C@@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC=C3C=CC=CC3=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CC=CN=C5)=O)CO)=O)C)CC6=CC=C(O)C=C6)=O)CC(N)=O
Reference





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