Afatinib( Purity > 99% by HPLC)

Product Name: Afatinib
 CAT#: A-1122

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 Synonym:BIBW-2992; BIBW 2992; BIBW2992. trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok. ,

Afatinib Chemical Structure
Afatinibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Afatinib, also know as BIBW 2992, is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor.
Technical Data

Purity: >99%
CAS#: 439081-18-2
Chemical Formula:C24H25ClFN5O3
Molecular Weight:485.94
Afatinib MSDSAfatinib CoA

IUPAC/Chemical name: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide.
Canonical SMILES:
Reference





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