Product Name: AnastrozoleRequest Anastrozole
Synonym:US brand name: Arimidex. Abbreviation: ANAS. Code names: ICI-D1033 ZD-1033. ,
Anastrozole Chemical Structure
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Biological Activity Anastrazole is a nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth.
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