Cabozantinib( Purity > 99% by HPLC)

Product Name: Cabozantinib
 CAT#: A-1089

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 Synonym:Cabozantinib, XL-184, XL184. BMS 907351; BMS-907351; BMS907351; trade name Cometriq ,

Cabozantinib Chemical Structure
Cabozantinibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Cabozantinib, also known as XL-184 or BMS-907351, is an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several tyrosine receptor kinases. Specifically, cabozantinib appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. Cabozantinib has also been shown to inhibit mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (Flt3) and tyrosine-protein kinase receptor (Tie-2). Cabozantinib was approved by the U.S. FDA in November 2012 for the treatment of medullary thyroid cancer.
Technical Data

Purity: >99%
CAS#:849217-68-1
Chemical Formula:C28H24FN3O5
Molecular Weight:501.50
Cabozantinib MSDSCabozantinib CoA

IUPAC/Chemical name:N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide
Canonical SMILES:
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