Carfilzomib (PR-171)( Purity > 99% by HPLC)

Product Name: Carfilzomib (PR-171)
 CAT#: A-1098

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 Synonym:PR171; PR-171; PR 171; Carflizomib, brand name: Kyprolis ,

Carfilzomib (PR-171) Chemical Structure
Carfilzomib (PR-171)chemical structure

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IUPAC/Chemical name:

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Biological Activity
Carfilzomib, also known as PR-171 is a tetrapeptide epoxyketone and an epoxomicin derivate with potential antineoplastic activity. Carfilzomib irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Carfilzomib was approved by the FDA for use in patients with relapsed and refractory multiple myeloma on 20 July 2012. Onyx expects to launch the drug in the U.S. on 1 August 2012. When it launches, it will cost $10,000 per 28-day cycle, making it the most expensive FDA-approved drug for multiple myeloma.
Technical Data

Purity: >99%
Chemical Formula:C40H57N5O7
Molecular Weight:719.91
Carfilzomib (PR-171) MSDSCarfilzomib (PR-171) CoA

IUPAC/Chemical name: (S)-4-methyl-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide
Canonical SMILES: CC(C)C[C@H](NC([C@@H](NC(CN1CCOCC1)=O)CCC2=CC=CC=C2)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C([C@]4(C)OC4)=O)=O)=O.

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