Crizotinib( Purity > 99% by HPLC)

Product Name: Crizotinib
 CAT#: A-1031

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 Synonym: PF-02341066; PF02341066; PF 02341066; PF-2341066; PF2341066; PF 2341066; US brand name: Xalkori; ,

Crizotinib Chemical Structure
Crizotinibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Crizotinib, also known as PF-02341066, is an orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. Crizotinib was approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and childre. Crizotinib inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations. On August 26, 2011, the U.S. Food and Drug Administration approved crizotinib (Xalkori) to treat certain late-stage (locally advanced or metastatic) non-small cell lung cancers that express the abnormal anaplastic lymphoma kinase (ALK) gene.
Technical Data

Purity: >99%
Chemical Formula:C21H23Cl3FN5O
Molecular Weight:486.8
Crizotinib MSDSCrizotinib CoA

IUPAC/Chemical name:(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
Canonical SMILES:NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@@H](C4=C(Cl)C=CC(F)=C4Cl)C

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