Product Name: Cytarabine hydrochlorideRequest Cytarabine hydrochloride
Synonym:arabinofuranosylcytosine; arabinosylcytosine; aracytidine; beta-cytosine arabinoside; cytarabine hydrochloride; cytarabinum; cytosine arabinoside. cytosine arabinosine hydrochloride. US brand names ,
Cytarabine hydrochloride Chemical Structure
5 stars, based on 1836 reviewsIUPAC/Chemical name:
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Biological Activity Cytarabine is an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair.
IUPAC/Chemical name:4-amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
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