Product Name: DabrafenibRequest Dabrafenib
Synonym:GSK2118436A (Dabrafenib); GSK 2118436A; GSK-2118436A; GSK-2118436B (Dabrafenib Mesylate); GSK2118436B; GSK 2118436B. Trade name: Tafinlar. ,
Dabrafenib Chemical Structure
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Biological ActivityDabrafenib, also known as GSK2118436, is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. On May 29, 2013, FDA approved this drug.
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