Dabrafenib( Purity > 99% by HPLC)

Product Name: Dabrafenib
 CAT#: A-1220

Request Dabrafenib
 Synonym:GSK2118436A (Dabrafenib); GSK 2118436A; GSK-2118436A; GSK-2118436B (Dabrafenib Mesylate); GSK2118436B; GSK 2118436B. Trade name: Tafinlar. ,

Dabrafenib Chemical Structure
Dabrafenibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Dabrafenib, also known as GSK2118436, is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. On May 29, 2013, FDA approved this drug.
Technical Data

Purity: >99%
CAS#:1195765-45-7
Chemical Formula:C23H20F3N5O2S2
Molecular Weight:519.56
Dabrafenib MSDSDabrafenib CoA

IUPAC/Chemical name:N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Canonical SMILES:
Reference





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