Product Name: Dactinomycin (Actinomycin D)Request Dactinomycin (Actinomycin D)
Synonym:Abbreviation: DACT; ACT-D; actinomycin C1; actinomycin D; actinomycin I1; actinomycin IV; actinomycin X 1; actinomycin-[thr-val-pro-sar-meval]; dactinomycine; meractinomycin; US brand names: Cosmeg ,
Dactinomycin (Actinomycin D) Chemical Structure
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Biological ActivityDactinomycin (also known generically as Actinomycin D ) is the most significant member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. As one of the older chemotherapy drugs, it has been used for many years. Actinomycin D was the first antibiotic shown to have anti-cancer activity. It was first isolated by Selman Waksman and his co-worker H. B. Woodruff in 1940. It was approved by the US FDA on December 10, 1964 and launched by Merck Sharp and Dohme under the trade name Cosmegen.
IUPAC/Chemical name: 2-amino-N1,N9-bis(6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Canonical SMILES: O=C(C1=C(N)C(C(C)=C2OC3=C(N=C21)C(C(N[C@H](C(N[C@@H](C(N4CCC[C@]4(C(N(CC(N([C@H](C5=O)C(C)C)C)=O)C)=O)[H])=O)C(C)C)=O)[C@H](O5)C)=O)=CC=C3C)=O)N[C@@H]6C(N[C@H](C(C)C)C(N7[C@](CCC7)([H])C(N(C)CC(N(C)[C@@H](C(C)C)C(O[C@@H]6C)=O)=O)=O)=O)=O
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