Dasatinib( Purity > 99% by HPLC)

Product Name: Dasatinib
 CAT#: A-2070

Request Dasatinib
 Synonym:US brand name: Sprycel. Code name: BMS-354825; BMS354825; BMS354825. Dasatinib. ,

Dasatinib Chemical Structure
Dasatinibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
Technical Data

Purity: >99%
CAS#:863127-77-9
Chemical Formula:C22H28ClN7O3S
Molecular Weight:506.02
Dasatinib MSDSDasatinib CoA

IUPAC/Chemical name:N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide monohydrate.
Canonical SMILES:
Reference





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