Product Name: DoxifluridineRequest Doxifluridine
Synonym: doxifluridine; Furtulon; Flutron; doxyfluridine; 5'-Doxifluridine; Furtulon (TN); 5'-Deoxy-5-fluorouridine; 5-Fluorodeoxyuridine; 5'-Dfur Abbreviation: 5-DFUR. Chemical structure name: 5'-deoxy-5-flu ,
Doxifluridine Chemical Structure
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Biological Activity Doxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
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