Product Name: Doxorubicin Free BaseRequest Doxorubicin Free Base
Synonym: ADR; chloridrato de doxorrubicina. US brand names: Adriamycin PFS Adriamycin RDF; Foreign brand names: Adriacin; Adriblastina; Adriblastine; Adrimedac; DOXO-CELL; Doxolem; Doxorubin; Farmiblastina; R ,
Doxorubicin Free Base Chemical Structure
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Biological ActivityDoxorubicin free base, aslo call doxorubicin, is an anthracycline antibiotic with antineoplastic activity. Approved API for cancer therapeutic use doxorubicin HCl. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
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