Product Name: Doxorubicin HClRequest Doxorubicin HCl
Synonym: ADR; chloridrato de doxorrubicina. US brand names: Adriamycin PFS Adriamycin RDF; Foreign brand names: Adriacin; Adriblastina; Adriblastine; Adrimedac; DOXO-CELL; Doxolem; Doxorubin; Farmiblastina; R ,
Doxorubicin HCl Chemical Structure
5 stars, based on 1836 reviewsIUPAC/Chemical name:
Price of Doxorubicin HCl We offer a substantial discount on larger orders,
please inquire via email@example.com
or Fax: 1-201-884-1288 (USA Fax#)
Biological ActivityDoxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
IUPAC/Chemical name:(8S,10S)-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
Purchase(buy) Doxorubicin HCl at Active Biochem
and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.