Eltrombopag( Purity > 99% by HPLC)

Product Name: Eltrombopag
 CAT#: A-2081

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 Synonym:SB-497115; SB497115; SB 497115; SB-497115-GR; Eltrombopag olamine; Brand name: PROMACTA?? ,

Eltrombopag Chemical Structure
Eltrombopagchemical structure

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IUPAC/Chemical name:

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Biological Activity
Eltrombopag, also known as SB-497115, is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was approved by FDA in November 20, 2008. Eltrombopag received FDA breakthrough treatment designation in February 2014 for patients with aplastic anemia for which immunosuppression has not been successful. It has been shown to produce a trilineage hematopoesis in some patients with aplastic anemia, resulting in increased platelet counts, along with red and white blood cell counts.
Technical Data

Purity: >99%
CAS#:496775-61-2
Chemical Formula:C25H22N4O4
Molecular Weight:442.47
Eltrombopag MSDSEltrombopag CoA

IUPAC/Chemical name:3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Canonical SMILES:
Reference





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