Product Name: Estramustine phosphate sodiumRequest Estramustine phosphate sodium
Synonym:estramustine Phosphate; US brand name: Emcyt. Foreign brand name: Estracyt. Abbreviation: EM. Code names: Leo-299; Ro 22-2296/000 ,
Estramustine phosphate sodium Chemical Structure
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Biological Activity Estramustine phosphate sodium is a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.
IUPAC/Chemical name:(8R,9S,13S,14S,17S)-13-methyl-17-(phosphonooxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl bis(2-chloroethyl)carbamate hydrate
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