Product Name: FingolimodRequest Fingolimod
Synonym:Code mane: FTY-720; FTY720; FTY 720. Fingolimod; AC1L332W; CHEMBL314854; CHEBI:63115; LS-187221; CID107970; Band name: Gilenia and Gilenya. ,
Fingolimod Chemical Structure
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Biological ActivityFingolimod (rINN, codenamed FTY720) is an immunosuppressive drug. It is derived from the myriocin (ISP-1) metabolite of the fungus Isaria sinclairii. It is a structural analogue of sphingosine and gets phosphorylated by sphingosine kinases in the cell (most importantly sphingosine kinase 2). The molecular biology of phospho-fingolimod is thought to lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1. It can sequester lymphocytes in lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosis and was originally proposed as a anti-rejection medication indicated post-transplantation. It has been reported to stimulate the repair process of glial cells and precursor cells after injury. Fingolimod has also been reported to be a cannabinoid receptor antagonist, a cPLA2 inhibitor and a ceramide synthase inhibitor.
IUPAC/Chemical name:2-amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride.
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