Product Name: FlutamideRequest Flutamide
Synonym: Flucinom; Flugerel; Niftolid. US brand name: Eulexin. Foreign brand names: Apimid; Chimax; Drogenil; Euflex; Eulexine; Flucinome; Fluken; Flulem; Flutabene; Flutacan; Fluta-Gry; Flutamex; Flutamin; ,
Flutamide Chemical Structure
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Biological ActivityFlutamide is a toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression.
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