Product Name: FosaprepitantRequest Fosaprepitant
Synonym: Fosaprepitant; Fosaprepitant dimeglumine. brand name: Emend; Inemend. Code name: UNII-D35FM8T64X; MK-0517; MK 0517; MK0517. ,
Fosaprepitant Chemical Structure
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Biological Activity Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant. Fosaprepitant was developed by Merck & Co. and was approved by the United States Food and Drug Administration (FDA) on January 25, 2008, and by the European Medicines Agency (EMA) on January 11 of the same year. Merck is developing this drug for chemotherapy-induced nausea and vomiting (CINV) in adolescents, children and infants.
IUPAC/Chemical name:(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Canonical SMILES: O=C(N1)N(P(O)(O)=O)N=C1CN2CCO[C@H](O[C@H](C)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)[C@@H]2C4=CC=C(F)C=C4.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC
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