Product Name: FotemustineRequest Fotemustine
Synonym: Foreign brand name: Muphoran. Code name: S 10036. ,
Fotemustine Chemical Structure
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Biological Activity Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
IUPAC/Chemical name:diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
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