Product Name: FulvestrantRequest Fulvestrant
Synonym:ZD9238; ZD-9238; ZD 9238; ICI 182,780; ICI-182,780; ICI182,780; ICI182780; ICI 182780; ICI-182780; ZM-182780; ZM 182780; ZM182780; Fulvestrant; US brand name: Faslodex. ,
Fulvestrant Chemical Structure
5 stars, based on 1836 reviewsIUPAC/Chemical name:
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Biological Activity Fulvestrant is a synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines.
Canonical SMILES: OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])[C@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)=O)CC2=C1
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