Product Name: Idarubicin hydrochlorideRequest Idarubicin hydrochloride
Synonym: 4-Demethoxydaunomycin; 4-demethoxydaunorubicin; DMDR. US brand name: Idamycin; IDAMYCIN PFS. Abbreviations: 4-DMDR; IDA ,
Idarubicin hydrochloride Chemical Structure
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Biological Activity Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds.
IUPAC/Chemical name:(7S,9S)-9-acetyl-7-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
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