Product Name: IfosfamideRequest Ifosfamide
Synonym: Ifomide; Iphosphamid; iphosphamide; Isoendoxan; Iso-Endoxan; isophosphamide; Naxamide; US brand names: Cyfos; Ifex; Ifosfamidum; Foreign brand names: Holoxan; Holoxane; IFO-Cell; Ifolem; Ifomida; Ifo ,
Ifosfamide Chemical Structure
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Biological ActivityIfosfamide is a synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.
IUPAC/Chemical name:3-(2-chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide
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