Imatinib Mesylate( Purity > 99% by HPLC)

Product Name: Imatinib Mesylate
 CAT#: A-2118

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 Synonym:US brand name: Gleevec. Foreign brand name: Glivec. Code names: CGP 57148; CGP57148B; STI-571; STI-571. ,

Imatinib Mesylate Chemical Structure
Imatinib Mesylatechemical structure

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IUPAC/Chemical name:

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Biological Activity
Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).
Technical Data

Purity: >99%
Chemical Formula:C30H35N7O4S
Molecular Weight:589.71
Imatinib Mesylate MSDSImatinib Mesylate CoA

IUPAC/Chemical name:N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide methanesulfonate
Canonical SMILES:

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