Product Name: Ingenol MebutateRequest Ingenol Mebutate
Synonym:PEP005; PEP005; PEP 005; 3-Angeloylingenol; 3-Ingenyl angelate; Ingenol 3-angelate; Ingenol mebutate; Brand name: Picato. ,
Ingenol Mebutate Chemical Structure
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Biological ActivityIngenol mebutate, also known as ingenol-3-angelate ( trade name Picato), is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. A gel formulation of the drug has been approved by the U.S. Food and Drug Administration (FDA) for the topical treatment of actinic keratosis.Two different strengths of the gel are approved for use on either the face and scalp (0.015%) or the trunk and extremities (0.05%), respectively. Results from four multicenter, randomized, double-blind studies have shown that ingenol mebutate gel applied topically for 2 to 3 days is effective for field treatment of actinic keratoses.
IUPAC/Chemical name:(Z)-(1aS,5R,5aS,6S,9R)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e]annulen-6-yl 2-methylbut-2-enoate
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