Irinotecan hydrochloride( Purity > 99% by HPLC)

Product Name: Irinotecan hydrochloride
 CAT#: A-2121

Request Irinotecan hydrochloride
 Synonym: camptothecin-11; irinotecan; irinotecan HCl; US brand name: Camptosar. Foreign brand name: Campto. Code names: CPT-11; U-101440E. ,

Irinotecan hydrochloride Chemical Structure
Irinotecan hydrochloridechemical structure

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IUPAC/Chemical name:

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Biological Activity
Irinotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
Technical Data

Purity: >99%
CAS#: 136572-09-3
Chemical Formula:C33H45ClN4O9 or C33H38N4O¡¤HCl¡¤3H2O
Molecular Weight:677.18
Irinotecan hydrochloride MSDSIrinotecan hydrochloride CoA

IUPAC/Chemical name:(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate.
Canonical SMILES:: O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C3C4=NC5=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C5C(CC)=C4CN31.[H]Cl.[H]O[H].[H]O[H].[H]O[H]
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