Product Name: IxabepiloneRequest Ixabepilone
Synonym:BMS-247550; BMS247550; BMS 247550; Azaepothilone B??MS 247550-1. Trade name: Ixempra ,
Ixabepilone Chemical Structure
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Biological ActivityIxabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007.
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