Ixabepilone( Purity > 99% by HPLC)

Product Name: Ixabepilone
 CAT#: A-2122

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 Synonym:BMS-247550; BMS247550; BMS 247550; Azaepothilone B??MS 247550-1. Trade name: Ixempra ,

Ixabepilone Chemical Structure
Ixabepilonechemical structure

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Biological Activity
Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007.
Technical Data

Purity: >99%
CAS#:219989-84-1
Chemical Formula:C27H42N2O5S
Molecular Weight:506.70
Ixabepilone MSDSIxabepilone CoA

IUPAC/Chemical name:(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((Z)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
Canonical SMILES:O=C(C[C@@H]1O)N[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@H]3[C@@](O3)(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(C1(C)C)=O
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