Mercaptopurine( Purity > 99% by HPLC)

Product Name: Mercaptopurine
 CAT#: A-2140

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 Synonym: 6-Thiohypoxanthine; 6-hiopurine; 6-mercaptopurine; 6-Mercaptopurine Monohydrate; 6-Purinethiol; 6-Thiopurine; 6-Thioxopurine; Azathiopurine; Leupurin; Mercapurin; Mern; Purimethol; US brand names: Me ,

Mercaptopurine Chemical Structure
Mercaptopurinechemical structure

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IUPAC/Chemical name:

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Biological Activity
Mercaptopurine is a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis
Technical Data

Purity: >99%
CAS#:50-44-2
Chemical Formula:C5H4N4S
Molecular Weight:152.18
Mercaptopurine MSDSMercaptopurine CoA

IUPAC/Chemical name: 1H-purine-6(7H)-thione.
Canonical SMILES:
Reference





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