Product Name: MethotrexateRequest Methotrexate
Synonym: alpha-methopterin; amethopterin; Methotrexatum; methylaminopterin; Metotrexato. US brand names: Abitrexate; Folex; Folex PFS; Methotrexate LPF; Mexate; Mexate-AQ; Foreign brand names: Brimexate; Emte ,
Methotrexate Chemical Structure
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Biological ActivityMethotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
IUPAC/Chemical name:(S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid.
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