Product Name: Mitomycin CRequest Mitomycin C
Synonym:mitomycine C; mitomycin-X. US brand names: Mitozytrex; Mutamycin. Foreign brand names: Ametycine; Mitocin-C; Mitolem; Mito-Medac; Mutamycine. Abbreviations: MITC; MITO; MITO-C; MTC. Code ,
Mitomycin C Chemical Structure
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Biological Activitymitomycine C is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.
IUPAC/Chemical name:((1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate
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