Olaparib (AZD-2281)( Purity > 99% by HPLC)

Product Name: Olaparib (AZD-2281)
 CAT#: A-1125

Request Olaparib (AZD-2281)
 Synonym: 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one ,

Olaparib (AZD-2281) Chemical Structure
Olaparib (AZD-2281)chemical structure

5 stars, based on 1836 reviews

IUPAC/Chemical name:

Price of Olaparib (AZD-2281)

We offer a substantial discount on larger orders,
please inquire via sales@activebiochem.com
or Fax: 1-201-884-1288 (USA Fax#)


Biological Activity
Olaparib, also known as AZD-2281 or KU-59436, is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Olaparib was approved in 2014 for treating advanced ovarian cancer.
Technical Data

Purity: >99%
CAS#:763113-22-0
Chemical Formula:C24H23FN4O3
Molecular Weight:434.46
Olaparib (AZD-2281) MSDSOlaparib (AZD-2281) CoA

IUPAC/Chemical name:KU-59436, KU-0059436. AZD2281; AZD=2281; AZD 2281
Canonical SMILES:
Reference





Purchase(buy) Olaparib (AZD-2281) at Active Biochem and the United State(U.S.), Germany, Japan, France,United Kingdom(UK),Switzerland, Australia distributors.