Palbociclib Hydrochloride ( Purity > 99% by HPLC)

Product Name: Palbociclib Hydrochloride
 CAT#: A-1030

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 Synonym: PD 0332991; PD 332991; PD0332991; PD-0332991; Palbociclib ,

Palbociclib Hydrochloride Chemical Structure
Palbociclib Hydrochloride chemical structure

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IUPAC/Chemical name:

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Biological Activity
Palbociclib, also known as PD0332991, is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. PD-0332991 selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation; inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50 = 0.011 μmol/L) and Cdk6 (IC50 = 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases. Palbociclib was approved on 2/3/2015 for treatment of advanced (metastatic) breast cancer.
Technical Data

Purity: >99%
CAS#: 827022-32-2
Chemical Formula:C24H29N7O2HCl
Molecular Weight:483.99
Palbociclib Hydrochloride MSDSPalbociclib Hydrochloride CoA

IUPAC/Chemical name:6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
Canonical SMILES:
Reference





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