Panobinostat( Purity > 99% by HPLC)

Product Name: Panobinostat
 CAT#: A-2172

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 Synonym:LBH-589; LBH 589; LBH589; NVP-LBH-589; NVP LBH-589; Panobinostat; trade name Farydak ,

Panobinostat Chemical Structure
Panobinostatchemical structure

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IUPAC/Chemical name:

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Biological Activity
Panobinostat, also known as NVP LBH-589 or LBH-589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. On 2/23/2015, it received FDA accelerated approval for use in patients with multiple myeloma who had received at least 2 previous treatments, including bortezomib and an immunomodulatory agent.
Technical Data

Purity: >99%
CAS#:404950-80-7
Chemical Formula:C21H23N3O2
Molecular Weight:349.43
Panobinostat MSDSPanobinostat CoA

IUPAC/Chemical name:(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide
Canonical SMILES:
Reference





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