Plicamycin( Purity > 99% by HPLC)

Product Name: Plicamycin
 CAT#: A-2181

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 Synonym: aureolic acid; mithramycin. US brand name: Mithracin. Foreign brand name: Mithracine. Abbreviation: MTH. Code names: A-2371; PA-144 ,

Plicamycin Chemical Structure
Plicamycinchemical structure

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IUPAC/Chemical name:

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Biological Activity
Plicamycin, also known as mithramycin or Mithramycin A is an antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption.
Technical Data

Purity: >99%
CAS#:18378-89-7
Chemical Formula:C52H76O24
Molecular Weight:1085.14
Plicamycin MSDSPlicamycin CoA

IUPAC/Chemical name:(2S,3S)-3-((1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl)-2-(((2S,4R,5R,6R)-4-(((2S,4R,5R,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-8,9-dihydroxy-7-methyl-3,4-dihydroanthracen-1(2H)-one
Canonical SMILES:
Reference





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