Product Name: PlicamycinRequest Plicamycin
Synonym: aureolic acid; mithramycin. US brand name: Mithracin. Foreign brand name: Mithracine. Abbreviation: MTH. Code names: A-2371; PA-144 ,
Plicamycin Chemical Structure
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Biological Activity Plicamycin, also known as mithramycin or Mithramycin A is an antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption.
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