Product Name: PorfiromycinRequest Porfiromycin
Synonym:methyl mitomycin; methyl mitomycin C; Methylmitomycin; porfiromycine porphyromycin; US brand name: Promycin. Code names: ENT-50825; U-14743; N-methylmitomycin C. ,
Porfiromycin Chemical Structure
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Biological ActivityPorfiromycin is an N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
IUPAC/Chemical name:((1aS,8S,8aR,8bS)-6-amino-8a-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate
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