Pralatrexate( Purity > 99% by HPLC)

Product Name: Pralatrexate
 CAT#: A-2199

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 Synonym:PDX??0-Propargyl-10-deazaaminopterin??05589, Folotyn. ,

Pralatrexate Chemical Structure
Pralatrexatechemical structure

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IUPAC/Chemical name:

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Biological Activity
Pralatrexate (PDX; trade name Folotyn) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death. Efficient intracellular polyglutamylation of pralatrexate results in higher intracellular concentrations compared to non-polyglutamylated pralatrexate, which is more readily effuxed by the MRP (multidrug resistance protein) drug efflux pump. RFC-1, an oncofetal protein expressed at highest levels during embryonic development, may be overexpressed on the cell surfaces of various cancer cell types.
Technical Data

Purity: >99%
Chemical Formula: C23H23N7O5
Molecular Weight:477.47
Pralatrexate MSDSPralatrexate CoA

IUPAC/Chemical name:N-(4-{1-[(2,4-diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic acid
Canonical SMILES:

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