Radotinib( Purity > 99% by HPLC)

Product Name: Radotinib
 CAT#: A-2205

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 Synonym:Radotinib; IY5511 HCl. trade name Supect. ,

Radotinib Chemical Structure
Radotinibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Radotinib, also known as IY-5511, is an orally available and second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.
Technical Data

Purity: >99%
Chemical Formula:C27H21F3N8O
Molecular Weight:530.50
Radotinib MSDSRadotinib CoA

IUPAC/Chemical name:4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzamide
Canonical SMILES:

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