Product Name: Sunitinib MalatRequest Sunitinib Malat
Synonym: Synonym: sunitinib. US brand name: Sutent. Abbreviation: SU11248; Code names: SU011248; SU11248. ,
Sunitinib Malat Chemical Structure
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Biological ActivitySunitinib malate, also known as SU11248, is the orally bioavailable malate salt of an indolinone-based tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.
IUPAC/Chemical name:(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide malate
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