Tacrolimus( Purity > 99% by HPLC)

Product Name: Tacrolimus
 CAT#: A-2217

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 Synonym:US brand names: Prograf; Protopic. Foreign brand name: Advagraf Code name: FK 506. ,

Tacrolimus Chemical Structure
Tacrolimuschemical structure

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IUPAC/Chemical name:

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Biological Activity
Tacrolimus, also known as FK-506, is a macrolide isolated from the fungus Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
Technical Data

Purity: >99%
CAS#:104987-11-3
Chemical Formula:C44H69NO12
Molecular Weight:804.02
Tacrolimus MSDSTacrolimus CoA

IUPAC/Chemical name:[3S [3R*[E(1S*,3S*,4S*)], 4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]] -5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Canonical SMILES:
Reference





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