Tamibarotene( Purity > 99% by HPLC)

Product Name: Tamibarotene
 CAT#: A-2224

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 Synonym:retinobenzoic acid. Foreign brand names: Amnoid, AMNOLAKE. Code name: Am-80. ,

Tamibarotene Chemical Structure
Tamibarotenechemical structure

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IUPAC/Chemical name:

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Biological Activity
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA. In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.
Technical Data

Purity: >99%
CAS#:94497-51-5
Chemical Formula:C22H25NO3
Molecular Weight:351.44
Tamibarotene MSDSTamibarotene CoA

IUPAC/Chemical name:4-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
Canonical SMILES:
Reference





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