Tegafur( Purity > 99% by HPLC)

Product Name: Tegafur
 CAT#: A-2221

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 Synonym: oral fluorouracil-uracil; Uracil and Ftorafur; Uracil and Tegafur; Uracil and Tetrahydrofuranyl-5-Fluorouracil; Uracil/Tegafur (UFT). Foreign brand name: Uftoral; Abbreviation: UFT. ,

Tegafur Chemical Structure
Tegafurchemical structure

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IUPAC/Chemical name:

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Biological Activity
Tegafur (INN) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil. When metabolized, it becomes 5-FU. Tegafur-uracil is a formulated therapeutic oral agent consisting of a combination of the 5-fluorouracil (5-FU) congener prodrug tegafur (tetrahydrofuranyl-5-fluorouracil) and uracil (1:4). The high concentration of uracil reversibly inhibits the uracil-reducing enzyme dihydropyrimidine dehydrogenase (DPD), thereby inhibiting first-pass DPD-mediated hepatic metabolism of the uracil analogue 5-FU and permitting administration of 5-FU as the orally bioavailable prodrug tegafur. Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.
Technical Data

Purity: >99%
CAS#:17902-23-7
Chemical Formula:C8H9FN2O3
Molecular Weight:200.17
Tegafur MSDSTegafur CoA

IUPAC/Chemical name:-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Canonical SMILES:
Reference





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