Product Name: TeriflunomideRequest Teriflunomide
Synonym:Teriflunomide; A77 1726; A771726; A77-1726; HMR1726; HMR-1726; HMR 1726; Brande name: Aubagio ,
Teriflunomide Chemical Structure
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Biological Activity Teriflunomide, aslo known as A77 1726 (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide. Teriflunomide is an immunomodulatory drug inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate dehydrogenase. It is uncertain whether this explains its effect on MS lesions. Teriflunomide inhibits rapidly dividing cells, including activated T cells, which are thought to drive the disease process in MS. Teriflunomide may decrease the risk of infections compared to chemotherapy-like drugs because of its more-limited effects on the immune system. It has been found that teriflunomide blocks the transcription factor NF-κB. It also inhibits tyrosine kinase enzymes, but only in high doses not clinically used. The drug was approved by the FDA on September 13, 2012.
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