Toceranib( Purity > 99% by HPLC)

Product Name: Toceranib
 CAT#: A-2232

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 Synonym:SU11654; SU-11654; SU 11654; PHA-291639; PHA291639; PHA 291639. Generic name: Toceranib; Brand name: Palladia ,

Toceranib Chemical Structure
Toceranibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Toceranib is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) by AB Science), toceranib is the only dog-specific anti-cancer drug approved by the U.S. Food and Drug Administration. It is marketed as Palladia as its phosphate salt, toceranib phosphate (INN) by Pfizer. It was developed by SUGEN as SU11654, a sister compound to sunitinib, which was later approved for human therapies. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic effect.
Technical Data

Purity: >99%
Chemical Formula:C22H28FN4O6P
Molecular Weight:494.45
Toceranib MSDSToceranib CoA

IUPAC/Chemical name:(Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-N-(2-(pyrrolidin-1-yl)ethyl)-1H-pyrrole-3-carboxamide phosphate
Canonical SMILES:O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN4CCCC4.O=P(O)(O)O

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