Product Name: Trametinib DMSO solvateRequest Trametinib DMSO solvate
Synonym:Trametinib DMSO solvate, GSK-1120212 DMSO solvate;Trametinib;JTP-74057; JTP 74057; JTP74057; GSK-1120212;GSK1120212;GSK 1120212. ,
Trametinib DMSO solvate Chemical Structure
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Biological Activity Trametinib DMSO solvate is a solvated form of trametinib at 1:1 molar ratio of trametinib to dimethyl sulfoxide. Trametinib, also known as GSK1120212, GSK212 or JTP74057, is an approved and new targeted drug for the treatment of melanoma. It is a powerful and selective MEK1/MEK2 inhibitor which can effectively prevent cancer cell proliferating and can induce cell apoptosis, and increase the life of patients.
IUPAC/Chemical name:N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)
Canonical SMILES: CC1=C2C(C(N(C3CC3)C(N2C4=CC(NC(C)=O)=CC=C4)=O)=O)=C(NC5=C(F)C=C(I)C=C5)N(C)C1=O.CS(C)=O
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