Trametinib( Purity > 99% by HPLC)

Product Name: Trametinib
 CAT#: A-1258

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 Synonym:GSK 1120212, GSK-1120212; GSK1120212; JTP-74057; Trametinib. Brand name: Mekinist. ,

Trametinib Chemical Structure
Trametinibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Trametinib, also known as GSK1120212, is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. On May 29, 2013, FDA approved Trametinib.
Technical Data

Purity: >99%
Chemical Formula:C26H23FIN5O4
Molecular Weight:615.39
Trametinib MSDSTrametinib CoA

IUPAC/Chemical name:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
Canonical SMILES:

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