Product Name: TrametinibRequest Trametinib
Synonym:GSK 1120212, GSK-1120212; GSK1120212; JTP-74057; Trametinib. Brand name: Mekinist. ,
Trametinib Chemical Structure
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Biological ActivityTrametinib, also known as GSK1120212, is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. On May 29, 2013, FDA approved Trametinib.
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