Valrubicin( Purity > 99% by HPLC)

Product Name: Valrubicin
 CAT#: A-2241

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 Synonym:US brand name: Valstar. Foreign brand name: Valtaxin. Code name: AD 32. Chemical structure name: N-trifluoroacetyladriamycin-14-valerate. ,

Valrubicin Chemical Structure
Valrubicinchemical structure

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IUPAC/Chemical name:

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Biological Activity
valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations.
Technical Data

Purity: >99%
Chemical Formula:C34H36F3NO13
Molecular Weight:723.64
Valrubicin MSDSValrubicin CoA

IUPAC/Chemical name:2-oxo-2-((2S,4S)-2,5,12-trihydroxy-4-(((2S,4S,5S,6S)-5-hydroxy-6-methyl-4-(2,2,2-trifluoroacetamido)tetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethyl pentanoate
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