Vandetanib( Purity > 99% by HPLC)

Product Name: Vandetanib
 CAT#: A-2242

Request Vandetanib
 Synonym:AZD-6474; AZD 6474; AZD6474; ZD6474; ZD 6474; ZD-6474; CHEBI:38942; vandetanib; Brand name: Zactim; caprelsa. ,

Vandetanib Chemical Structure
Vandetanibchemical structure

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IUPAC/Chemical name:

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Biological Activity
Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. Vandetanib was the first drug to be approved by FDA (April 2011) for treatment of late-stage (metastatic) medullary thyroid cancer in adult patients who are ineligible for surgery. Vandetanib was first initially marketed without a trade name, and is being marketed under the trade name Caprelsa since August 2011.
Technical Data

Purity: >99%
CAS#:443913-73-3
Chemical Formula:C22H24BrFN4O2
Molecular Weight:475.35
Vandetanib MSDSVandetanib CoA

IUPAC/Chemical name:N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Canonical SMILES:
Reference





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