masoprocol( Purity > 99% by HPLC)

Product Name: masoprocol
 CAT#: A-2137

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 Synonym:masoprocol, nordihydroguaiaretic acid, NDGA, and actinex. ,

masoprocol Chemical Structure
masoprocolchemical structure

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IUPAC/Chemical name:

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Biological Activity
NDGA (Nordihydroguaiaretic acid), also known as masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase.
Technical Data

Purity: >99%
Chemical Formula:C18H22O4
Molecular Weight:302.36488
masoprocol MSDSmasoprocol CoA

IUPAC/Chemical name:4,4'-((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)
Canonical SMILES:

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